Compositions and methods for controlling plant pests
AssigneeSyngenta Participations AG
InventorsMatthew Richard Bramlett, Katherine Seguin, Vance Cary Kramer, Mark Scott Rose
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Abstract
Novel insecticidal proteins isolated from Bacillus thuringiensis that are active against lepidopteran insect pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform various prokaryotic and eukaryotic organisms to express the insecticidal proteins. These recombinant organisms can be used to control lepidopteran insects in various environments.
Claims17
A chimeric gene comprising a heterologous promoter operably linked to a nucleic acid molecule comprising a nucleotide sequence that encodes a protein toxic to at least European corn borer (Ostrinia nubilalis), wherein the nucleotide sequence (a) comprises SEQ ID NO:1;
- or (b) encodes a protein comprising an amino acid sequence that has at least 95% sequence identity across its full length with SEQ ID NO:21;
- or (c) is a synthetic sequence of (a) or (b) that has codons optimized for expression in a transgenic organism.
A synthetic nucleic acid molecule comprising a nucleotide sequence that encodes a protein that is toxic to at least European corn borer (Ostrinia nubilalis), wherein the nucleotide sequence has codons optimized for expression in a transgenic organism compared to SEQ ID NO:1 and encodes an amino acid sequence that has at least 95% sequence identity across its full length with SEQ ID NO:21.
A mutant insecticidal protein that is toxic to at least European corn borer (Ostrinia nubilalis), wherein the protein comprises an amino acid sequence that has at least 95% sequence identity across its full length to SEQ ID NO:21 and has one or more amino acid substitutions compared to SEQ ID NO:16.
Dependencies are inferred from the claim text.