Methods for treating red blood cells
AssigneeViacell, Inc.
InventorDaniel G. Ericson
Life of this patent
Estimating the term…
Abstract
Methods for storing or rejuvenating blood involve contacting blood with a blood storage composition or a blood rejuvenating composition that include D-ribose and a nucleoside other than inosine (e.g., guanosine).
Claims20
A method of storing blood, the method comprising:
- contacting red blood cells with a blood storage composition effective to maintain a normal physiological level of 2,3-diphosphoglycerate (2,3-DPG) and reduce time-related decrease in ATP in the red blood cells, the composition comprising:
- D-ribose;
- and
- a nucleoside other than inosine.
A method of rejuvenating blood, the method comprising contacting red blood cells with a blood rejuvenating composition effective to produce a normal physiological level of 2,3-diphosphoglycerate (2,3-DPG) and reduce time-related decrease in ATP in the red blood cells, the composition comprising:
- D-ribose;
- and
- a nucleoside other than inosine.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having a 2,3-diphosphoglycerate value lower than the value for freshly drawn blood;
- and
- mixing the red blood cells with a blood rejuvenating composition under conditions effective to increase the 2,3-diphosphoglycerate value,
- wherein the blood rejuvenating composition comprises guanosine in an amount effective to increase the 2,3-diphosphoglycerate value to a normal physiological level and reduce time-related decrease in ATP.
A method of rejuvenating blood, the method comprising:
- providing red blood cells having an adenosine triphosphate value lower than the value for freshly drawn blood;
- and
- mixing the red blood cells with a blood rejuvenating composition under conditions effective to increase the adenosine triphosphate value and reduce time-related decrease in ATP, the blood rejuvenating composition comprising D-ribose and guanosine.
Dependencies are inferred from the claim text.