Method for manufacturing 7alpha-alkoxyoxacephem intermediate compound
AssigneesDongdo Co., Ltd., Tianjin Greenpine Pharma Co., Ltd.
InventorDong Chan Kim
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Abstract
The present disclosure provides a method for preparing a 7α-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solvent to form a reaction product such that unreacted halogen compound remains; and adding metal alkoxide and reducing agent to the reaction product with the unreacted halogen compound remaining, thereby to produce a compound represented by a following chemical formula 2: where R is a Cl, Br, I, halogen derivative, R1 is a carboxyl protecting group including diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H), and R2 is an alkyl group having 1 to 4 carbon atoms.
Claims12
A method for preparing a 7α-alkoxyoxacephem compound, the method comprising a process (S1) including:
- (a) reacting a compound represented by a following chemical formula 1 with chlorine in an organic solvent to form a reaction product such that unreacted chlorine remains;
- and
- (b) adding metal alkoxide and reducing agent to the reaction product with the unreacted chlorine remaining, thereby to produce a compound represented by a following chemical formula 2:
- where R is a Cl, Br, or I, R1 is diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl, or hydrogen (H) as a carboxyl protecting group,
- where R is a Cl, Br, or I, R1 is diphenylmethyl, p-methoxybenzyl, p-nitrobenzyl or hydrogen (H) as a carboxyl protecting group, and R2 is an alkyl group having 1 to 4 carbon atoms.
Dependencies are inferred from the claim text.