Factor involved in latent infection with herpesvirus, and use thereof
AssigneesVirus Ikagaku Kenkyusho Inc., Japan Tobacco Inc.
InventorsKazuhiro Kondo, Nobuyuki Kobayashi
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Abstract
Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
Claims9
A nucleic acid being one of the following nucleic acids (a) and (b):
- (a) a nucleic acid encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1, wherein said nucleic acid further comprises a fluorescent label or a chemiluminescent label attached to the nucleic acid;
- and
- (b) a nucleic acid comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2, wherein said nucleic acid further comprises a fluorescent label or a chemiluminescent label attached to the nucleic acid.
A recombinant vector comprising:
- a vector;
- and
- a nucleic acid inserted into said vector being one of the following nucleic acids (a) and (b):
- (a) a nucleic acid encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1;
- and
- (b) a nucleic acid comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2,
- wherein the recombinant vector comprises a promoter,
- wherein said promoter is selected from the group consisting of a CMV immediate-early promoter, a HSV thymidine kinase promoter, a phage λPL promoter, an E. coli lad promoter, an E. coli lacZ promoter, a T3 promoter, a T7 promoter, a gpt promoter, a λPR promoter, a trp promoter, a tac promoter, a GFAP promoter, a SV40 early promoter and late promoter, a retrovirus LTR promoter and a metallothionein promoter.
A recombinant vector comprising:
- a vector;
- and
- a nucleic acid inserted into said vector being one of the following nucleic acids (a) and (b):
- (a) a nucleic acid encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1;
- and
- (b) a nucleic acid comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2,
- wherein the recombinant vector comprises an enhancer selected from the group consisting of a SV40 enhancer, an early promoter enhancer of a cytomegalovirus, a polyoma enhancer on the late side of a replication origin, and an adenovirus enhancer.
A nucleic acid being one of the following cDNA sequences (a) and (b):
- (a) a cDNA sequence encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1;
- and
- (b) a cDNA sequence comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2.
A nucleic acid being one of the following DNA sequences (a) and (b):
- (a) a DNA sequence including no noncoding sequences encoding a protein having the amino acid sequence shown in SEQ ID NO:
- 1;
- and
- (b) a DNA sequence including no noncoding sequences comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.