Methods and compositions for live attenuated viruses
AssigneeTakeda Vaccines, Inc.
InventorsDan Stinchcomb, Jorge E. Osorio, O'Neil Wiggan
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Abstract
Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation of the live, attenuated virus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated virus composition may include at least one carbohydrate, at least one protein and at least one high molecular weight surfactants for reducing inactivation and/or degradation of the live, attenuated virus.
Claims14
A virus composition comprising:
- one or more live, attenuated flaviviruses;
- and a stabilizing composition comprising serum albumin and trehalose,
- wherein the one or more live, attenuated flaviviruses consists of one or more Dengue viruses;
- wherein the serum albumin is serum albumin from a vertebrate species, and is present at a concentration of 0.001 to 3.0% (w/v);
- wherein the trehalose is present at a concentration of at least 15% (w/v);
- and
- wherein the composition is capable of reducing the inactivation of the one or more live, attenuated Dengue viruses.
A method for decreasing inactivation of one or more live, attenuated Dengue viruses comprising:
- combining one or more live, attenuated Dengue viruses with a stabilizing composition comprising serum albumin and trehalose,
- wherein the serum albumin is serum albumin from a vertebrate species, and is present at a concentration of 0.001 to 3.0% (w/v);
- wherein the trehalose is present at a concentration of at least 15% (w/v);
- and
- wherein the composition is capable of reducing the inactivation of the one or more live, attenuated Dengue viruses.
A kit for decreasing inactivation of Dengue viruses comprising:
- at least one container;
- and
- a composition comprising one or more live, attenuated Dengue viruses;
- and a stabilizing composition comprising:
- serum albumin and trehalose,
- wherein the serum albumin is serum albumin from a vertebrate species, and is present at a concentration of 0.001 to 3.0% (w/v);
- wherein the trehalose is present at a concentration of at least 15% (w/v);
- and
- wherein the composition is capable of reducing the inactivation of the one or more live, attenuated Dengue viruses.
Dependencies are inferred from the claim text.