Use of parvovirus for eliminating cancer stem cells (CSCs)
AssigneesDeutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
InventorsJean Rommelaere, Jeannine Lacroix, Joerg Schlehofer, Olaf Witt, Elisabeth Hedwig Deubzer, Sonja Kern, Christel Herold-Mende, Karsten Geletneky, Barbara Leuchs
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Abstract
Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.
Claims8
A method of combating cancer stem cells (CSCs) in a subject having metastatic cancer disease, comprising administering to said subject a composition comprising parvovirus H-1 (H-1PV) effective for therapeutically destroying said CSCs which are characterized by the expression of stem cell markers CD133, nestin, and/or SOX2.
A method of combating cancer stem cells (CSCs) in a subject suffering cancer relapse, comprising administering to said subject a composition comprising parvovirus H-1 (H-1PV) effective for therapeutically destroying said CSCs which are characterized by the expression of stem cell markers CD133, nestin, and/or SOX2.
Dependencies are inferred from the claim text.