US 10,522,261 B2 · Solution target for cyclotron production of radiometals

Abstract

Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Claims11

Dependent claims

A synthesis system comprising:

a cyclotron operable for bombarding a target material in a target cavity of a solution target with protons or deuterons;
and
a kit for isolation of a radionuclide from a solution including the radionuclide, the solution having been produced by the bombarding of the target material in the target cavity of the solution target with protons or deuterons, the kit comprising:
a column including a sorbent to adsorb the produced radionuclide on the sorbent, wherein the sorbent comprises a hydroxamate resin;
and an eluent for eluting the radionuclide off the sorbent,
wherein the radionuclide is selected from 68Ga, 89Zr, 64Cu, 86Y, 63Zn, 61Cu, 99mTC, 45Ti, 52Mn and 44Sc.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/311,052Filed 15 May 2015 · us provisional application

Priority

15 May 2014

Published

US 2017/0221594 A13 Aug 2017

Granted

31 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

B01J 20/22
Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof:…
B01D 15/08
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor: selective adsorption, e.g. chromatography
B01J 20/3085
Processes for preparing, regenerating, or reactivating: chemical treatments not covered by groups B01J20/3007 - B01J20/3078
B01J 20/3092
Processes for preparing, regenerating, or reactivating: packing of a container, e.g. packing a cartridge or column

Solution target for cyclotron production of radiometals

Life of this patent

Solution target for cyclotron production of radiometals

Life of this patent

Abstract

Claims11