US 10,520,494 B2 · Flattop (FLTP) is a novel biomarker for beta cell maturation

Abstract

The present invention relates to the use of the biomarker Flattop (Fltp) for distinguishing mature β cells from immature progenitor β cells. The present invention further relates to a method for distinguishing a mature β cell from an immature progenitor β cell, the method comprising: determining the presence or absence of the biomarker Flattop (Fltp) in a β cell; wherein the presence of Fltp in the cell indicates that the cell is a mature β cell and wherein the absence of Fltp in the cell indicates that the cell is an immature progenitor β cell. Furthermore, the present invention relates to a method of identifying a compound suitable for differentiating immature progenitor β cells into mature β cells as well as to a method of identifying a compound suitable for preventing the de-differentiating of mature β cells.

Claims10

Dependent claims

A method of identifying a compound suitable for differentiating immature progenitor β cells into mature β cells, the method comprising:

(a) contacting a cell population comprising immature progenitor β cells with a test compound;
and
(b) subsequently determining the presence or expression level of the biomarker Flattop (Fltp) in the β cells comprised in the cell population;
wherein the presence of Fltp, or an increased expression level of Fltp, in the cells comprised in the cell population after the contacting with the test compound is indicative of a compound suitable for differentiating immature progenitor β cells into mature β cells.

1 more element

Dependencies are inferred from the claim text.

Flattop (FLTP) is a novel biomarker for beta cell maturation

Life of this patent

Flattop (FLTP) is a novel biomarker for beta cell maturation

Life of this patent

Abstract

Claims10