Virus causing respiratory tract illness in susceptible mammals
AssigneesViroNovative BV, Erasmus University Medical Center
InventorsJan Cornelius De Jong, Ronaldus Adrianus Maria Fouchier, Bernadetta Gerarda Van Den Hoogen, Albertus Dominicus Marcellinus Erasmus Osterhaus, Jan Groen
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Abstract
The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single-stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.
Claims13
A kit for determining the presence of metapneumovirus (MPV) in a mammalian subject, the kit comprising:
- a DNA probe of at least 10 nucleotides that specifically hybridizes to a target polynucleotide,
- wherein the target polynucleotide comprises a sequence encoding a polypeptide that is at least 90% identical to SEQ ID NO:21 or the complement of the sequence, and
- wherein the DNA probe does not specifically hybridize to a polynucleotide from avian pneumovirus (APV).
A method for detecting a human metapneumovirus infection in a mammal, the method comprising:
- detecting, in a sample from the mammal, the presence of a component of human metapneumovirus by reacting the sample with a DNA probe of at least 10 nucleotides in length that specifically hybridizes to a target polynucleotide,
- wherein the target polynucleotide comprises a sequence encoding a polypeptide that is at least 90% identical to SEQ ID NO:21 or the complement of the sequence, and
- wherein the DNA probe does not specifically hybridize to a polynucleotide from avian pneumovirus (APV).
Dependencies are inferred from the claim text.