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US 10,519,515 B2Granted
Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
AssigneeCedars-Sinai Medical Center
InventorsMark Pimentel, Ruchi Mathur, Christopher Chang
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Abstract
The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
Claims16
A method, comprising:
- subjecting a biological sample from a subject to analysis for methanogen quantity, wherein the analysis comprises using quantitative polymerase chain reaction (qPCR);
- selecting a statin for the subject having the methanogen quantity higher than a reference value that is about 10,000 cfu per ml of the biological sample when the biological sample is stool subjected to the analysis using the qPCR, based on the recognition that the statin is appropriate for subjects who have a methanogen quantity higher than the reference value;
- and
- administering an effective amount of the selected statin to the subject, wherein the subject has constipation predominant irritable bowel syndrome (C-IBS) caused by or associated with having a high methanogen quantity.
1 more element
A method, comprising:
- subjecting a biological sample from a subject to analysis for methanogen quantity, wherein the analysis comprises using quantitative polymerase chain reaction (qPCR);
- selecting a statin for the subject determined to have a susceptibility to constipation predominant irritable bowel syndrome (C-IBS) caused by or associated with having a high methanogen quantity when the methanogen quantity is higher than a reference value that is about 10,000 cfu per ml of the biological sample wherein the biological sample is stool subjected to the analysis using the qPCR, based on the recognition that the statin is appropriate for subjects who have a methanogen quantity higher than the reference value;
- and
- administering an effective amount of the statin to the subject.
1 more element
Dependencies are inferred from the claim text.