STK32C gene relevant to breast cancer and use thereof
AssigneeDongguk University Industry-Academic Cooperation Foundation
InventorChang-Hoon Lee
Life of this patent
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Abstract
The present invention relates to the serine threonine kinase 32C (STK32C) gene relevant to breast cancer and a use thereof, and particularly, to a composition for the diagnosis, prevention, or treatment of breast cancer using the STK32C gene. In the present invention, changes in breast cancer cells according to STK32C gene expression differences were identified, and a breast cancer inhibitory effect according to the inhibition of expression of the STK32C gene and YB-1, which is a substrate protein, were newly verified, and thus target therapies are expected in treatment of breast cancer through more fundamental approaches.
Claims9
A method of screening a breast cancer therapeutic material, the method comprising the following processes:
- a) treating serine threonine kinase 32C (STK32C)-expressing cells with a test material;
- b) measuring an expression or activity level of STK32C in the cells;
- and
- c) selecting a test material that inhibits expression or activity of STK32C when compared to a control not treated with the test material, as a breast cancer therapeutic material.
A method of diagnosing and treating a breast cancer, the method comprising the following processes:
- a) measuring an expression or activity level of serine threonine kinase 32C (STK32C) in a subject-derived biological sample using an agent that measures an expression or activity level of STK32C;
- b) diagnosing a case in which the measured expression or activity level of STK32C is higher than that of a normal control, as having breast cancer, and
- c) administering an expression or activity inhibitor of serine threonine kinase 32C (STK32C) to the subject.
A method of treating breast cancer, the method comprising administering an expression or activity inhibitor of serine threonine kinase 32C (STK32C) to a subject in need.
Dependencies are inferred from the claim text.