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US 10,519,499 B2Granted
Hybrid nanopore sensors
AssigneeIllumina, Inc.
InventorsBoyan Boyanov, Jeffrey G Mandell, Kevin L Gunderson, Jingwei Bai, Liangliang Qiang, Bradley Baas
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Abstract
The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids.
Claims18
A detection apparatus comprising:
- (a) a solid support comprising an array of solid state nanopores;
- (b) a plurality of lipid nanodiscs on a surface of the solid support, wherein each of the lipid nanodiscs comprises a lipid bilayer and forms a seal at each of the solid state nanopores, and wherein the lipid nanodiscs are non-contiguous from each other, and are separated from each other by interstitial regions on the surface of the solid support;
- and
- (c) a plurality of protein nanopores inserted in the lipid nanodiscs to create apertures in each of the seals.
1 more element
Dependencies are inferred from the claim text.