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US 10,519,495 B2Granted
Extreme ultraviolet radiation in genomic sequencing and other applications
AssigneeSupriya Jaiswal
InventorSupriya Jaiswal
Life of this patent
Estimating the term…
Abstract
Methods, apparatus, and processes which use Extreme ultraviolet radiation (EUV) and/or soft X-ray wavelengths to read, image, edit, locate, identify, map, alter, delete, repair and sequence genes are described. An EUV scanning tool which allows high throughput genomic scanning of DNA, RNA and protein sequences is also described. A database which records characteristic absorption spectra of gene sequences is also described.
Claims23
An apparatus for detecting absorption by a macromolecule comprising:
- i. a radiation source configured to transmit radiation having a wavelength from 0.1 nm to 250 nm;
- ii. one or more focusing components configured to focus the radiation to a spot size of less than 20 nm;
- ii. a macromolecule comprising a sequence of monomers configured to absorb at least a portion of the radiation;
- iv. a detector capable of detecting radiation absorbed by the macromolecule, where each monomer in the macromolecule has a unique signature in the absorption spectrum;
- and
- v. a decomposer configured to convert the absorption spectrum from the detector into an identified sequence of monomers of the macromolecule, said monomers selected from the group consisting of cytosine, guanine, adenine, thymine, and uracil.
3 more elements
A system for locating, reading, identifying and editing one or more gene sequences, comprising:
- an EUV or soft X ray light source configured to transmit light having a wavelength in the range 0.1 nm to 250 nm,
- a mirror, lens, or reflector for focusing the light spot size,
- a biomaterial to be sequenced,
- a measured absorption spectrum or transmission spectrum;
- and
- a decomposer configured to convert the measured absorption or transmission spectrum into an identified sequence of monomers of the biomaterial, said monomers selected from the group consisting of cytosine, guanine, adenine, thymine, and uracil.
3 more elements
Dependencies are inferred from the claim text.