Use of miRNA-214 inhibitor in inhibiting regulatory cells
AssigneeJiangsu Micromedmark Biotech Co., Ltd.
InventorsChenyu Zhang, Ke Zeng, Yuan Yin, Xing Cai, Junfeng Zhang
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Abstract
Provided is a use of miRNA-214 inhibitor in inhibiting regulatory T cells (Treg cells). The microRNA-214 (miRNA-214) can promote Treg cells, and can assist tumors in immune escape. The experiments demonstrates that the inhibition of miRNA-214 can inhibit the growth of Treg cells, thus inhibiting the growth of tumors. Therefore, miRNA-214 can be used for developing an anti-tumour drug or a drug inhibiting immune response hyperactivity.
Claims7
A method for treating sarcoma or lung cancer by administering a safe and effective dose of microvesicles to a subject in need thereof so as to treat the sarcoma or lung cancer by inhibiting Treg cells, wherein said microvesicles contain a miRNA-214 inhibitor which is an anti-sense nucleotide sequence of miRNA-214 or a precursor thereof.
Dependencies are inferred from the claim text.