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US 10,519,246 B2Granted
Anti-fibroblast activation protein (FAP) antibodies for treatment and diagnosis
AssigneePhilogen S.P.A.
InventorsRoberto DeLuca, Catherine Pemberton Ross
Life of this patent
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Abstract
The present invention relates to the diagnosis and treatment of diseases, such as cancer and inflammatory disorders. The invention provides, and involves the use of, antibodies that bind fibroblast activation protein (FAP).
Claims13
An antibody molecule that binds fibroblast activation protein (FAP), wherein the antibody molecule comprises a VH domain comprising a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, and a VL domain comprising a framework and a set of complementarity determining regions LCDR1, LCDR2 and LCDR3, wherein:
- HCDR1 has the amino add sequence of SEQ ID NO:
- 3;
- HCDR2 has the amino add sequence of SEQ ID NO:
- 4;
- HCDR3 has the amino add sequence of SEQ ID NO:
- 5;
- LCDR1 has the amino add sequence of SEQ ID NO:
- 6;
- LCDR2 has the amino add sequence of SEQ ID NO:
- 7;
- and
- LCDR3 has the amino add sequence of SEQ ID NO:
- 8.
10 more elements
Dependencies are inferred from the claim text.