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US 10,519,238 B2Granted
Anti-galectin-1 monoclonal antibodies and fragments thereof
AssigneeDana-Farber Cancer Institute, Inc.
InventorsMargaret A. Shipp, Jing Ouyang, Scott J. Rodig
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Abstract
The present invention is based, in part, on the discovery of anti-galectm-1 (Gal 1.) monodonai antibodies useful for diagnostic and prognostic applications, as well as immunoglobulins, polypeptides, and nucleic acids thereof.
Claims17
A monoclonal antibody, or antigen-binding fragment thereof, that binds galectin-1 (Gal1) wherein the monoclonal antibody comprises:
- a) a heavy chain sequence comprising a CDR-H1, a CDR-H2, and a CDR-H3 sequences, wherein the CDR-H1 sequence consists of an amino acid sequence of RYNMH (SEQ ID NO:
- 23), the CDR-H2 sequence consists of an amino acid sequence of RIYPGNGDTSYNQKFKG (SEQ ID NO:
- 26), and the CDR-H3 sequence consists of an amino acid sequence of WDY (amino acid residues 118-120 of SEQ ID NO:
- 7);
- and
- b) a light chain sequence comprising a CDR-L1, a CDR-L2, and a CDR-L3 sequences, wherein the CDR-L1 sequence consists of an amino acid sequence of KSSQSLLDSDGKTYLN (SEQ ID NO:
- 12), the CDR-L2 sequence consists of an amino acid sequence of LLSKLDS (SEQ ID NO:
- 15), and the CDR-L3 sequence consists of an amino acid sequence of WQGTHFPYT (SEQ ID NO:
- 18).
6 more elements
Dependencies are inferred from the claim text.