Nucleic acids encoding IL-8 antibodies
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana, Yuki Iwayanagi, Yuji Hori, Genki Nakamura, Masaru Muraoka
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Abstract
One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.
Claims33
An isolated nucleic acid encoding an anti-IL-8 antibody which comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein
- (a) the VH comprises:
- (i) a HVR-H1 comprising the amino acid sequence of SEQ ID NO:67,
- (ii) a HVR-H2 comprising the amino acid sequence of SEQ ID NO:73,
- (iii) a HVR-H3 comprising the amino acid sequence of SEQ ID NO:74;
- and
- (b) the VL comprises:
- (i) a HVR-L1 comprising the amino acid sequence of SEQ ID NO:70,
- (ii) a HVR-L2 comprising the amino acid sequence of SEQ ID NO:75, and
- (iii) a HVR-L3 comprising the amino acid sequence of SEQ ID NO:76.
An isolated nucleic acid encoding an anti-IL-8 antibody which comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:78 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:79.
Dependencies are inferred from the claim text.