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US 10,519,228 B2Granted
Methods for reducing drug-induced liver injury
AssigneeTen Peaks LLC
InventorsSundar Srinivasan, Christina Chow
Life of this patent
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Abstract
The present disclosure provides methods of treating a patient with infliximab or alternative therapies to reduce the risk of developing, and/or severity of, an adverse drug reaction such as drug-induced liver injury. The methods include identifying patients at risk for developing DILI by determining the presence or absence of one or more HLA alleles in the patients.
Claims10
A method of treating a population of patients having an autoimmune disease with infliximab, the method comprising
- providing a first population of patients having an autoimmune disease;
- excluding only patients having an HLA profile comprising HLA-B*39:01 from the first population of patients;
- treating the population of patients not excluded from the first population with infliximab;
- and
- treating the excluded patients with an autoimmune disease therapy that is not infliximab.
2 more elements
Dependencies are inferred from the claim text.