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US 10,519,227 B2Granted
Methods for reducing drug-induced liver injury
AssigneeTen Peaks LLC
InventorsSundar Srinivasan, Christina Chow
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods of treating a patient with infliximab or alternative therapies to reduce the risk of developing, and/or severity of, an adverse drug reaction such as drug-induced liver injury. The methods include identifying patients at risk for developing DILI by determining the presence or absence of one or more HLA alleles in the patients.
Claims8
A method of treating a condition in a subject in need of infliximab therapy, comprising:
- identifying the subject as not having a genetic variation comprising the HLA-B*39:01 allele;
- and administering a therapeutically effective amount of infliximab to the subject, wherein the subject has a decreased risk of drug-induced liver injury (DILI), wherein the subject's decreased risk of DILI is associated with an absence of the genetic variation.
Dependencies are inferred from the claim text.