VEGF neutralizing prodrugs for the treatment of ocular conditions

A method for the treatment of one or more ocular conditions, the method comprising:

• intraocularly administering, by injecting into the aqueous humor, the vitreous body, or the lens of an eye, a pharmaceutical composition comprising:
• one or more pharmaceutically acceptable excipient(s);
• and
• a VEGF neutralizing carrier-linked prodrug comprising a VEGF neutralizing biologically active moiety covalently and reversibly bound to a reversible prodrug linker moiety, wherein the reversible prodrug linker moiety is attached to a hydrogel carrier moiety, either directly or via a spacer moiety;
• wherein the step of intraocularly administering comprises two intraocular administrations of the prodrug;
• and
• wherein a time period between the two intraocular administrations of the VEGF neutralizing prodrug is at least 10 weeks.