Antibodies to pyroglutamate amyloid-β and uses thereof
AssigneeJannsen Pharmaceutica, N.V.
InventorsMarc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
Life of this patent
Estimating the term…
Abstract
The invention provides an antibody or antigen binding fragments thereof that binds to 3pE Aβ and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other β-amyloid-related diseases.
Claims16
An isolated antibody or antigen binding fragment thereof which binds to amyloid β protein having pyroglutamate at the third amino acid residue (3pE Aβ) comprising
- a) a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:3,
- b) a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:4,
- c) a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:5,
- d) a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:
- 14,
- e) a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:
- 15, and
- f) a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:16.
An isolated antibody which binds to 3pE Aβ comprising
- a) a heavy chain of the amino acid sequence of SEQ ID NO:
- 1;
- and
- b) a light chain of the amino acid sequence of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.