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US 10,519,217 B2Granted
CD27L collectin fusion proteins and encoding nucleic acids
AssigneeApogenix AG
InventorsOliver Hill, Christian Gieffers, Meinolf Thiemann, Marcus Branschaedel
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Abstract
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
Claims20
A fusion protein comprising:
- (i) a TNF (tumor necrosis factor)-superfamily cytokine of CD27 ligand (CD27L) or a TNF receptor binding domain thereof, and
- (ii) a collectin trimerization domain comprising a neck domain or a neck and carbohydrate binding domain of surfactant protein-D,
- wherein (ii) is located C-terminally of (i).
Dependencies are inferred from the claim text.