Long-acting recombinant follicle-stimulating hormone and use thereof
AssigneeGuangzhou Vbio Pharma Co., Ltd.
InventorsYongmin Hou, Yao Lei, Henglu Deng
Life of this patent
Estimating the term…
Abstract
Disclosed in the present invention is a long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (referred to as hFSH-Fc for short) and a preparation method thereof, wherein the hFSH-Fc protein is a dimerized fusion protein and the amino acid sequence thereof successively comprises an hFSHβ subunit, CTP, an hFSHα subunit, a flexible peptide linker and human IgG2 Fc variant from N-terminal to C-terminal. Also disclosed in the present invention is the use of the recombinant hFSH-Fc fusion protein composition in preparing drugs in the animal breeding field.
Claims1
A method for animal breeding in a subject thereof, comprising administering a recombinant homodimeric hFSH-Fc fusion protein to the subject, wherein the recombinant homodimeric hFSH-Fc fusion protein with an amino acid sequence sequentially comprising an hFSH β-subunit, CTP, hFSH α-subunit, a flexible peptide linker, and human IgG2 Fc variant, from N-terminal to C-terminal,
- wherein said human IgG2 Fc variant comprises a hinge with a Pro331Ser mutation, CH2, and CH3 domains;
- and
- wherein the amino acid sequence of the fusion protein is set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.