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US 10,519,208 B2Granted
CD40L single-chain fusion polypeptides and encoding nucleic acids
AssigneeApogenix AG
InventorsOliver Hill, Christian Gieffers, Meinolf Thiemann
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Abstract
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Claims12
A single-chain fusion polypeptide comprising:
- (i) a first soluble CD40 ligand (CD40L) cytokine domain,
- (ii) a first peptide linker,
- (iii) a second soluble CD40L cytokine domain,
- (iv) a second peptide linker, and
- (v) a third soluble CD40L cytokine domain,
- wherein each of the soluble CD40L cytokine domains lacks a stalk region.
3 more elements
Dependencies are inferred from the claim text.