Compositions and methods for treating opioid tolerance
AssigneeGeorgia State University Research Foundation, Inc.
InventorsAnne Z. Murphy, Lori Eidson
Life of this patent
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Abstract
The present disclosure is directed to a method of treating morphine tolerance and/or symptoms associated therewith by administration to a subject in need thereof a DN-TNF polypeptide that inhibits the activity of soluble TNF- but not transmembrane TNF-α.
Claims9
A method of treating morphine tolerance and/or symptoms associated therewith comprising administering a therapeutically effective amount of a dominant negative TNF-α polypeptide to a subject in need thereof, whereby said symptoms are improved in said subject.
A method of increasing glutamate uptake in a patient in need thereof comprising administering to said patient a dominant negative TNF-α polypeptide, whereby glutamate uptake is increased as compared to glutamate uptake prior to said administration.
Dependencies are inferred from the claim text.