Compositions and methods for use of anion channel rhodopsins
AssigneeBoard of Regents, The University of Texas System
InventorsJohn Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
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Abstract
Methods and compositions used to identify and characterize a new class of rhodopsins derived from algae, which are highly sensitive and efficient anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
Claims12
A recombinant nucleic acid operatively linked to a heterologous promoter sequence, said recombinant nucleic acid comprising:
- (a) a sequence that encodes a polypeptide with at least 90% identity to an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 3;
- or
- (b) a sequence that encodes a polypeptide comprising 225 contiguous amino acids selected from the group consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 3.
A cDNA or mRNA comprising a nucleic acid sequence that encodes an amino acid sequence comprising SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.