Steroidal compound, composition containing the same and use thereof
AssigneeShenzhen TargetRx, Inc.
InventorsYihan Wang, Xingye Ren
Life of this patent
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Abstract
Disclosed are a steroidal compound as shown in formula (I) and a drug composition containing the same, or a crystal form, a pharmaceutically acceptable salt, a hydrate or solvate, a stereoisomer, a prodrug, a metabolite or an isotopic variant thereof. The compound can be used as a CYP17 enzyme inhibitor, and has better pharmacokinetic parameters, which can improve drug concentration of the compound in an animal, thereby improving the efficacy and safety of the drug, and in turn the compound may be applied in the preparation of the drug for treating CYP17 enzyme-related diseases (such as prostate cancer).
Claims14
A compound represented by Formula (I),
- wherein R1a, R1b, R1c, R1d, and R2 are each independently hydrogen, deuterium, or halogen;
- R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently hydrogen, halogen, or trifluoromethyl;
- X1 and X2 are methyl;
- Y is selected from hydrogen (H), acetyl, and an acetyl group substituted with one or more deuteriums;
- and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, tautomers and stereoisomers thereof, including mixtures of these compounds in all ratios;
- wherein the compound does not include non-deuterated compounds.
A compound, which is:
- or a pharmaceutically acceptable salt thereof.
A compound, which is:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.