Cyclic di-nucleotide compounds and methods of use

A compound, wherein the compound is of Formula Ic:

• wherein
• Z12 and Z15 are N;
• Z13, Z14, Z16, and Z17 are independently CH or N;
• R3 is n-propyl or 2,2,2-trifluoroethyl-O—;
• R4 is hydroxyl;
• R9 and R10 are independently hydroxyl;
• thiol;
• C1-6alkyl;
• C1-6alkyl functionalized with one or more halogen, thiol, hydroxyl, carboxyl, C1-6alkoxy, C1-6hydroxyalkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, or azido groups;
• C1-6alkoxy;
• C1-6alkoxy functionalized with one or more halogen, thiol, hydroxyl, carboxyl, C1-6hydroxyalkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, or azido groups;
• C3-5alkenyl-O—;
• C3-5alkynyl-O—;
• oligo(ethylene glycol);
• poly(ethylene glycol);
• borano (—BH3);
• or —NR7R8;
• R7 and R8 are independently hydrogen;
• C1-6alkyl;
• C1-6alkyl functionalized with one or more halogen, thiol, hydroxyl, carboxyl, C1-6alkoxy, C1-6hydroxyalkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, or azido groups;
• cyclic —(C1-6alkyl)-;
• cyclic —(C1-6alkyl)-functionalized with one or more halogen, thiol, hydroxyl, carboxyl, C1-6alkoxy, C1-6hydroxyalkoxy, amino, C1-6alkylamino, or di(C1-6alkyl)amino groups;
• cyclic —(C1-6oxaalkyl)-;
• or cyclic —(C1-6oxaalkyl)-functionalized with one or more halogen, thiol, hydroxyl, C1-6hydroxyalkoxy, amino, C1-6alkylamino, or di(C1-6alkyl)amino groups;
• or a pharmaceutically acceptable salt thereof.