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US 10,519,176 B2Granted
Crystalline forms
AssigneeThar Pharma, LLC
InventorsMazen Hanna, Ning Shan, Miranda L. Cheney, David R. Weyna, Paul K. Isbester, Xufeng Sun
Life of this patent
Estimating the term…
Abstract
Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.
Claims15
A pharmaceutical composition comprising
- (a) a crystalline form (A) of zoledronic acid:
- DL-lysine, wherein the crystalline form (A) has substantially the same PXRD diffractogram as FIG. 1;
- or has substantially the same PXRD diffractogram as FIG. 2, and
- (b) at least one pharmaceutically acceptable excipient (B),
- wherein the pharmaceutical composition comprises additional excess of cocrystal formers;
- wherein the pharmaceutical composition contains about 1% to about 99% by weight of the crystalline form (A) and 99% to 1% by weight of a pharmaceutically acceptable excipient (B).
3 more elements
Dependencies are inferred from the claim text.