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US 10,519,165 B2Granted
Processes for preparing ACC inhibitors and solid forms thereof
AssigneeGilead Sciences, Inc.
InventorsMichael Geier, Norihiro Ikemoto, Sean Liew, Mark E. Scott, Vimal Varghese
Life of this patent
Estimating the term…
Abstract
The present disclosure provides solid forms, including a salt or co-crystal, of Compound I: which exhibits Acetyl-CoA carboxylase (“ACC”) inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
Claims4
A method for preparing compound of formula (J):
- comprising the steps of:
- (a) contacting a compound of formula (R):
- with a compound of formula (S):
- under conditions sufficient to form a compound of formula (P):
- or a solvate or a hydrate thereof,
- (b) contacting a compound of formula (P), or a solvate or a hydrate thereof, with a base under conditions sufficient to form a compound of formula (O):
- or a salt, a solvate, or a hydrate thereof,
- (c) contacting a compound of formula (O), or a salt, a solvate, or a hydrate thereof, with a reductant and a catalyst under conditions sufficient to form a compound of formula (N):
- (d) contacting a compound of formula (N) with a compound of formula (M):
- under conditions sufficient to form a compound of formula (L):
- (e) contacting a compound of formula (L) with a reductant under conditions sufficient to form a compound of formula (K):
- and (f) contacting a compound of formula (K) with a reductant under conditions sufficient to form a compound of formula (J);
- wherein R4 is C1-3 alkyl and each R5 is independently an optionally substituted C1-6 alkyl or an optionally substituted C1-6 aryl.
10 more elements
A method for preparing compound of formula (J):
- comprising the steps of:
- (a) contacting a compound of formula (R):
- with a compound of formula (S):
- under conditions sufficient to form a compound of formula (P):
- or a solvate or a hydrate thereof,
- (b) contacting a compound of formula (P), or a solvate or a hydrate thereof, with a base under conditions sufficient to form a compound of formula (O):
- or a salt, a solvate, or a hydrate thereof,
- (c) contacting a compound of formula (O), or a salt, a solvate, or a hydrate thereof, with a reductant and a catalyst under conditions sufficient to form a compound of formula (N):
- (d) contacting a compound of formula (N) with a compound of formula (M):
- under conditions sufficient to form a compound of formula (L):
- and (g) contacting a compound of formula (L) with a reductant under conditions sufficient to form a compound of formula (J),
- wherein R4 is C1-3 alkyl and each R5 is independently an optionally substituted C1-6 alkyl or an optionally substituted C1-6 aryl.
9 more elements
Dependencies are inferred from the claim text.