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US 10,519,161 B2Granted
Methods of generating beta-lactamase resistant carbapenem compounds
AssigneeSouthern Methodist University
InventorJohn D. Buynak
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Abstract
The present invention includes compositions, methods of making and using novel carbapenem compounds including active agents, compounds, antibacterial agents, pharmaceutically acceptable salts of C1α-C1β di-substituted carbapenem compounds, C5α substituted carbapenem compounds, C6α-C6β di-substituted carbapenem compounds and combinations thereof.
Claims2
A composition comprising a carbapenem compound having the formula:
- or enantiomers or diastereoisomers thereof,
- wherein R1 and R1′ are independently selected from —H, —CH2CH2OH, —CHOHCH3, —CH2NHR*, —CH2OCONHR* and —CO2H;
- wherein R5 is selected from —CH2NHR*, —CH2OCONHR* and —CH2COCONHR*;
- wherein R6 and R6′ are independently selected from —H and —CHOHCH3;
- wherein R* is hydrogen;
- and
- wherein R2 is
- {2-[(iminomethyl)amino]ethyl}
- [5-(dimethylcarbamoyl) pyrrolidin-2-yl]
- or
- [(3S)-1-ethanimidoylpyrrolidin-3-yl]
8 more elements
An antibacterial composition comprising
- a carbapenem compound or its pharmaceutically acceptable salt as an active ingredient having the formula:
- or enantiomers or diastereoisomers thereof,
- wherein R1 and R1′ are independently selected from —H, —CH2CH2OH, —CHOHCH3, —CH2NHR*, —CH2OCONHR* and —CO2H;
- wherein R5 is selected from —CH2NHR*, —CH2OCONHR* and —CH2COCONHR*;
- wherein R6 and R6′ are independently selected from —H and —CHOHCH3;
- wherein R* is hydrogen;
- and
- wherein R2 is
- {2-[(iminomethyl)amino]ethyl}
- or
- [5-(dimethylcarbamoyl) pyrrolidin-2-yl]
- and a pharmaceutically acceptable carrier, excipient, binder or stabilizer.
9 more elements
Dependencies are inferred from the claim text.