Antiviral aliphatic ester prodrugs of tenofovir
AssigneesMerck Sharp & Dohme Corp., Idenix Pharmaceuticals, Inc.
InventorsJean-Laurent Paparin, Izzat Raheem, Houcine Rahali, Daniel Da Costa, David Dukhan
Life of this patent
Estimating the term…
Abstract
Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
Claims22
A compound that is:
- Isopropyl 2-((((R)—((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)((2-methyl-1-oxo-1-propoxypropan-2-yl)amino)phosphoryl)oxy)methyl)-5-fluorobenzoate;
- Isopropyl 2-((((S)—((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)((2-methyl-1-oxo-1-propoxypropan-2-yl)amino)phosphoryl)oxy)methyl)-5-fluorobenzoate;
- Isopropyl 3-((((R)—((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)((2-methyl-1-oxo-1-propoxypropan-2-yl)amino)phosphoryl)oxy)methyl)benzoate;
- or
- Isopropyl 3-((((S)—((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)((2-methyl-1-oxo-1-propoxypropan-2-yl)amino)phosphoryl)oxy)methyl)benzoate;
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.