7-substituted 1-pyridyl-naphthyridine-3-carboxylic acid amides and use thereof

A compound of the formula (II)

• wherein R2 represents a group of the formula
• in which
• * marks the point of attachment to the nitrogen atom of the amide moiety,
• R5A represents hydrogen or (C1-C4)-alkyl,
• R5B represents hydrogen, (C1-C4)-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl, trifluoromethyl, pentafluoroethyl, methoxymethyl or trifluoromethoxymethyl,
• R6 represents (C1-C4)-alkyl which is up to pentasubstituted by fluorine, or (C3-C5)-cycloalkyl which is up to tetrasubstituted by fluorine,
• Y1 is —(CH2)k—, —CF2—, —O—CH2—, —CH2—O— or —CH2—O—CH2—,
• in which
• k represents 0, 1, 2 or 3,
• R7 represents hydrogen, (C1-C2)-alkyl which is up to pentasubstituted by fluorine, or trifluoromethoxymethyl,
• L1 represents a bond or a group of the formula —C(R8AR8B)—(C(R9AR9B))m—,
• in which
• m represents 0 or 1,
• R8A represents hydrogen or methyl,
• R8B represents hydrogen, methyl, trifluoromethyl, pentafluoroethyl or trifluoromethoxymethyl,
• R9A and R9B independently represent hydrogen or methyl,
• Ar2 represents phenyl,
• where phenyl may be mono-to trisubstituted by identical or different substituents from the group consisting of fluorine, chlorine, (C1-C3)-alkyl, difluoromethoxymethyl, trifluoromethoxymethyl and trifluoromethyl,
• or
• represents a 5-to 10-membered bicyclic or tricyclic carbocycle,
• where the 5-to 10-membered bicyclic or tricyclic carbocycle may be up to trisubstituted, identically or differently, by (C1-C3)-alkyl and trifluoromethyl, and additionally up to tetrasubstituted by fluorine,
• Ar1 represents a pyridine ring which is attached via a ring carbon atom,
• where the pyridine ring may be mono-or disubstituted by fluorine, chlorine, cyano, methyl or trifluoromethyl, and
• Hal represents fluorine, chlorine, bromine or iodine, preferably chlorine.

A compound of the formula (IV)

• R1 represents NR3R4,
• in which
• R3 represents hydrogen, methyl, (C2-C4)-alkyl or (C3-C6)-cycloalkyl,
• where (C2-C4)-alkyl may be substituted by hydroxy or up to trisubstituted by fluorine and
• R4 represents (C1-C6)-alkyl, (C3-C6)-cycloalkyl, 3-to 6-membered saturated heterocyclyl or (C1-C4)-alkylsulfonyl,
• where (C1-C6)-alkyl, (C3-C6)-cycloalkyl and 3-to 6-membered saturated heterocyclyl may be up to trisubstituted by identical or different substituents from the group consisting of methyl, difluoromethyl, trifluoromethyl, hydroxy, hydroxycarbonyl, oxo, methoxy, difluoromethoxy, trifluoromethoxy and cyano and furthermore up to tetrasubstituted by fluorine,
• or
• R3 and R4 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated 3-to 6-membered monocyclic or 6-to 10-membered bicyclic heterocycle which may contain one or two further identical or different heteroatoms from the group consisting of N, O, S, SO and SO2 as ring members,
• where the 3-to 6-membered monocyclic and the 6-to 10-membered bicyclic heterocycle may each be substituted by 1 to 5 substituents independently selected from the group of (C1-C4)-alkyl, difluoromethyl, trifluoromethyl, hydroxy, hydroxycarbonyl, oxo, (C1-C3)-alkoxy, difluoromethoxy, trifluoromethoxy, cyano, (C1-C3)-alkoxycarbonyl, aminocarbonyl, mono-(C1-C3)-alkylaminocarbonyloxy, —NHC(═O)R14A and —CH2NHC(═O)R14B, and additionally up to tetrasubstituted by fluorine, in which
• R14A and R14B independently represent (C1-C3)-alkyl or cyclopropyl, and
• where (C1-C4)-alkyl may be mono-or disubstituted by identical or different substituents from the group consisting of hydroxy and (C1-C3)-alkoxy, and up to tetrasubstituted by fluorine,
• Ar1 represents a pyridine ring which is attached via a ring carbon atom,
• where the pyridine ring may be mono-or disubstituted by fluorine, chlorine, cyano, methyl or trifluoromethyl.