Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals
AssigneeNeomed Institute
InventorsMalken Bayrakdarian, Stephen Claridge, Andrew Griffin
Life of this patent
Estimating the term…
Abstract
This application relates to substituted [1,2,4]triazolo[4,3-a]pyridines of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted [1,2,4]triazolo[4,3-a]pyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
Claims8
A compound having the following Formula IIIb:
- wherein
- R1 is —C(Ra)(Rb)(Rc), where Ra and Rb independently represent hydrogen or a linear or branched C1-C6alkyl, or Ra and Rb are linked together to form a C3-C6cycloalkyl or a 3-7 membered heterocycloalkyl, and Rc is linear or branched C1-C6alkyl, C3-C6cycloalkyl, C6-C10aryl, 3-7 membered heterocycloalkyl, 5-8 membered heteroaryl, (C3-C6cycloalkyl)C1-C6alkyl, (3-7 membered heterocycloalkyl)C1-C6alkyl, (C6-C10aryl)C1-C6alkyl or (5-8 membered heteroaryl)C1-C6 alkyl;
- and
- each alkyl is unsubstituted or substituted with 1 to 3 groups being halogen, CN, alkoxy or haloalkoxy, and each of cycloalkyl, aryl, heterocycloalkyl and heteroaryl is unsubstituted or substituted by 1 to 3 groups being halogen, CN, alkyl, haloalkyl, alkoxy or haloalkoxy;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.