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US 10,519,145 B2Granted
Pyrazole-oxazolidinone compound for anti-hepatitis B virus
AssigneeShanghai Zhimeng Biopharma, Inc.
InventorHuanming Chen
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Abstract
The present invention discloses a pyrazole-oxazolidinone compound having anti-hepatitis B virus activity, which has the structure of formula (I), wherein each variable is as defined herein.
Claims20
A compound having formula I, or a pharmaceutically acceptable salt or enantiomer or tautomer thereof:
- wherein:
- each of R1, R2 and R3 is independently selected from hydrogen, halogen, optionally substituted alkyl, amino and hydroxyl;
- R4 and R5, together with the carbon atoms to which they are attached, form an optionally substituted five-membered heterocyclic or heteroaryl group containing at least one nitrogen atom, wherein —CH2— in the heterocyclic group is optionally replaced by —C(═O)—, —C(═S)—, or —C(═NH)—;
- R6is selected from deuterium, halogen, amino and hydroxyl;
- n is 0, 1 or 2;
- and
- Q is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted with one or more halogens.
4 more elements
A compound selected from:
- or a pharmaceutically acceptable salt or enantiomer or tautomer thereof.
Dependencies are inferred from the claim text.