Pyrimidine compound and pharmaceutical use thereof

A compound of Formula 1 or a pharmaceutically acceptable salt thereof:

• wherein, in Formula 1,
• R1 is hydrogen, a halogen, a hydroxy group, or a C1-4 alkoxy group,
• R2 is hydrogen, a halogen, a cyano group, a nitro group, an amino group, a carboxamide group, a formyl group, a halo C1-4 alkyl group, or a C1-4 alkyl group,
• R3 is hydrogen, a halo C1-4 alkyl group, a C1-4 alkyl group, a C2-4 alkenyl group, or a C2-4 alkynyl group,
• R4(s) are each independently a halogen, a hydroxy group, a cyano group, a nitro group, an amino group, —SRc, —S(═O)Rc, —S(═O)2Rc, a halo C1-4 alkyl group, a C1-4 alkoxy group, a hydroxy C1-4 alkyl group, a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, —NRaRb, —CO2Rb, or —CO—NRaRb,
• wherein, Ra and Rb are each independently hydrogen or a C1-6 alkyl group, and
• Rc is a C1-4 alkyl group or —NRaRb,
• k is an integer from 0 to 4,
• R5 and R6 are each independently hydrogen, a halogen, a hydroxy group, a nitro group, an amino group, a C1-4 alkoxy group, a hydroxy C1-4 alkyl group, a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, or a C3-10 cycloalkyl group,
• wherein, the C3-10 cycloalkyl group is each independently unsubstituted or substituted with a halogen, a C1-4 alkyl group, or a halo C1-4 alkyl group,
• R7 is hydrogen, a linear or branched C1-6 alkyl group, a C3-7 cycloalkyl group, a C3-9 heterocycloalkyl group, or a C1-4 alkoxy group,
• Y is a direct bond, —(CH2)m—, —O—, —O(CH2)m—, —(CH2)mO—, —C(═O)—, —NR9—, —(CH2)m—O—(CH2)n—, —CO(CH2)m—, —(CH2)m—CO—, —(CH2)m—CO—(CH2)n—, —(CH2)m—NR9—, —NR9(CH2)m—, —(CH2)m—NR9—(CH2)n—, —(CH2)mSO2—, —SO2(CH2)m—, or —(CH2)m—SO2—(CH2)n—,
• wherein R9 is hydrogen, a C1-4 alkyl group, a C3-10 cycloalkyl group, or a C3-9 heterocycloalkyl group, and
• m and n are each independently an integer from 1 to 3,
• Z is represented by Formula 2:
• wherein, in Formula 2,
• is a C3-10 cycloalkyl group or a C2-11 heterocycloalkyl group,
• R10 (s)) are each independently a halogen, a hydroxy group, a cyano group, a nitro group, an amino group, a thiol group, a formyl group, a linear or branched halo C1-4 alkyl group, a linear or branched C1-4 alkoxy group, a linear or branched hydroxy C1-4 alkyl group, a linear or branched C1-4 alkyl group, a linear or branched hydroxy C1-4 alkylcarbonyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, a C3-10 cycloalkyl group, a C2-9 heterocycloalkyl group, a hydroxy C2-9 heterocycloalkyl group, —NR11NR12, COR13, —COOR13, or —SO2R14,
• R11 and R12 are each independently hydrogen, a linear or branched hydroxy C1-4 alkyl group, a linear or branched halo C1-4 alkyl group, a linear or branched C1-4 alkyl group, a C2-4 alkenyl group, or a C2-4 alkynyl group,
• R13 is hydrogen, a hydroxy group, a hydroxy C1-4 alkyl group, a halo C1-4 alkyl group, a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, a C3-10 cycloalkyl group, or a C2-9 heterocycloalkyl group,
• R14 is a hydroxy group, a halo C1-4 alkyl group, a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, a C3-10 cycloalkyl group, a C2-9 heterocycloalkyl group, an aryl group, or —NRaRb, and
• q is an integer from 0 to 5.