US 10,519,140 B2 · Indolin-2-one derivatives

Abstract

The present invention is concerned with indolin-2-one derivatives of general formula wherein the substituents are defined in claim 1. The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co-morbid epilepsy.

Claims20

Dependent claims

A compound of formula

wherein
A is phenyl or a six membered heteroaryl group, containing one or two N atoms, selected from
or the amine group —NR1R2 may form together with two neighboring carbon atoms from the group A an additional fused ring, selected from
R1 and R2 are independently selected from hydrogen, C(O)-lower alkyl, cycloalkyl, —(CH2)2-lower alkoxy, lower alkyl or oxetanyl;
or R1 and R2 may form together with the N atom to which they are attach the group
and
R3 is hydrogen or lower alkyl;
or a pharmaceutically acceptable salt thereof.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/971,368Filed 4 May 2018 · continuation

Priority

EP 151933556 Nov 2015

Published

US 2018/0251450 A16 Sep 2018

Granted

31 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

C07D 403/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group…
A61P 25/08
Drugs for disorders of the nervous system: antiepileptics; Anticonvulsants
A61P 25/16
For treating abnormal movements, e.g. chorea, dyskinesia: anti-Parkinson drugs
A61P 25/18
Drugs for disorders of the nervous system: antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Indolin-2-one derivatives

Life of this patent

Indolin-2-one derivatives

Life of this patent

Abstract

Claims20