Dual inhibitors of PARP1 and CDK

A compound having a structure according to Formula I,

• or a pharmaceutically acceptable salt, or tautomer, thereof,
• wherein:
• M is a bond, —NH—, or —C(O)—;
• L is a aryl, arylalkyl, or heteroarylalkyl comprising a 5- to 20-membered heteroaryl having one to six heteroatoms selected from the group consisting of N, O, or S, each of which is optionally substituted with one or more halogen, aryl, 5- to 20-membered heteroaryl comprising one to six heteroatoms selected from the group consisting of N, O, or S, arylalkyl, or heteroarylalkyl comprising a 5- to 20 membered heteroaryl having one to six heteroatoms selected from the group consisting of N, O, or S, wherein the aryl, heteroaryl, arylalkyl, or heteroarylalkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, nitro, hydroxyl, SH, oxo, alkyl, alkenyl, alkynyl, aryl, 3- to 20-membered heterocyclyl comprising one to six heteroatoms selected from the group consisting of N, O, or S, NRgRh, NRgC(═O)Rh, NRgC(═O)NRgRh, NRgC(═O)ORh, NRgSO2Rh, OC(═O)NRgRh, ORg, SRg, SORg, SO2Rg, OSO2Rg, SO2ORg, ═NSO2Rg, and SO2NRgRh, C(═O)Rg, C(═O)ORg, —C(O)NRgRh, CH2SO2Rg, and CH2SO2NRgRh, wherein each of Rg and Rh are independently hydrogen, alkyl, alkenyl, or alkynyl;
• Q is CH2, O, S, or a bond;
• W and Y are independently CH or N, provided that at least one of W or Y is N, and when W is CH, Q is O or S;
• R1 and R2 are independently selected from hydrogen, halogen, alkyl, and 3- to 20-membered heterocyclyl comprising one to six heteroatoms selected from the group consisting of N, O, or S, each of which is optionally substituted with one or more halogen or alkyl;
• or R1 and R2 together with the atoms are to which they are attached form a C3-C20 carbocyclyl or 3- to 20-membered heterocyclyl comprising one to six heteroatoms selected from the group consisting of N, O, or S, each of which is optionally substituted with one or more halogen, alkyl, carbocyclyl comprising from 3 to 20 carbon atoms, oxo, —C(O)Rg, wherein Rg is alkyl, and —C(O)NRaRb, wherein each of Ra and Rb are independently selected from H or alkyl;
• and
• R9 is hydrogen, halogen, or alkyl.