Pyrazole compounds and methods of making and using same

A compound of Formula (IV):

• wherein:
• R1 is —N(R2)C(O)R15 or —N(H)SO2R15;
• R2 is H or C1-6alkyl;
• R3 is H or optionally substituted phenyl;
• R4 is H, halogen, —OR7, C1-6alkyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted C1-6alkyl-heterocycloalkyl, optionally substituted phenyl, optionally substituted heteroaryl, —CO2H, or —C(O)NR8R9;
• R5 is H, halogen, —CN, C1-6alkyl, C1-6haloalkyl, or phenyl;
• or
• R4 and R5 are combined to form an optionally substituted heterocycloalkyl ring or an optionally substituted heteroaryl ring;
• R6 is H, halogen or C1-6alkyl;
• R7 is H, C1-6 alkyl, optionally substituted phenyl, optionally substituted C1-6 alkyl-phenyl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, or —C1-6alkylC(O)NR10R11;
• R8 and R9 are each independently H, or C1-6alkyl;
• or R8 and R9 together with the nitrogen to which they are attached are combined to form an optionally substituted heterocycloalkyl ring;
• R10 and R11 are each independently H, or C1-6alkyl;
• or R10 and R11 together with the nitrogen to which they are attached are combined to form a heterocycloalkyl ring;
• R12 is H or C1-6alkyl;
• R13 is H or C1-6alkyl;
• and
• R15 is optionally substituted C1-6alkyl;
• or a solvate, hydrate, tautomer, N-oxide, stereoisomer, or pharmaceutically acceptable salt thereof.