Isocorydine derivatives, preparation method and use thereof
AssigneeLanzhou Institute of Chemical Physics, Chinese Academy of Sciences
InventorsJunxi Liu, Duolong Di
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Abstract
A derivative of isocorydine of formula I: wherein: R1═ X═N, C, C═C; n1=0, 1 R2═H, R1 Y═C, N R3═H, Cl, Br, F, CF3, OCH3, CH3, Z ═H, Cl, F, N; n2=0, 1 R4═NH2, CH2NH2, NHCO(CH2)n3CH3, CH2NHCO(CH2)n3CH3, n3=0, 1, 2. This derivative is prepared by amidation condensation reaction between an amino group of NICD and a carbonyl group of an aryl isocyanate, a carboxylic acid, or an acid chloride, or symmetrical amidation condensation reaction between an NICD and an aromatic amino group by solid phosgene. This derivative has anti-cancer activity in vivo and in vitro, and may be used for preventing and treating cancer.
Claims11
A compound of formula I:
- wherein in formula I:
- R1═
- wherein
- X═N, C, or C═C;
- n1=0 or 1;
- Y=C or N;
- Z═H, Cl, F, or N;
- n2=0 or 1;
- R3═H, Cl, Br, F, CF3, OCH3, CH3, or
- R4═NH2, CH2NH2, NHCO(CH2)n3CH3, or CH2NHCO(CH2)n3CH3, wherein n3=0, 1, or 2;
- and
- R2═H or R1.
Dependencies are inferred from the claim text.