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US 10,519,118 B2Granted
KDM1A inhibitors for the treatment of disease
AssigneeImago Biosciences, Inc.
InventorsHugh Y. Rienhoff, Jr., John M. McCall, Michael Clare, Cassandra Celatka, Amy E. Tapper
Life of this patent
Estimating the term…
Abstract
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
Claims22
A compound of Formula V:
- or a salt thereof, wherein:
- R1 and R2 are each independently chosen from alkyl, aminoalkyl, alkylsulfonylalkyl, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, phenyl, biphenyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl and R1 and R2, together with the nitrogen to which they attach, form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with between 0 and 3 R6 groups;
- R4b is hydrogen;
- R6a is chosen from heteroaryl, cyano, and S(O)2N(CH3)2;
- each R6 and R6b is independently chosen from hydrogen, halogen, alkyl, alkylsulfonylaryl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkoxy, haloaryl, alkoxyaryl, aryl, aryloxy, aralkyl, heterocycloalkyl, heteroaryl, alkylheteroaryl, heteroarylalkyl, cyano, alkoxy, alkoxyaryl, amino, alkylamino, dialkylamino, oxo, COR7, SO2R7, NHSO2R7, NHSO2NHR7, NHCOR7, NHCONHR7, CONHR7, and CONR7R8;
- and
- R7 and R8 are independently chosen from hydrogen, aryl, and lower alkyl;
- or R7 and R8 may be taken together to form a nitrogen-containing heterocycloalkyl or heteroaryl ring, which may be optionally substituted with lower alkyl.
5 more elements
A compound chosen from
- or a salt thereof.
Dependencies are inferred from the claim text.