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US 10,519,114 B2Granted
Peptidomimetics and methods of using the same
AssigneeThe Regents of the University of Michigan
InventorsHenry Mosberg, Deanna Montgomery, Aaron Bender, Anthony Nastase, Sean Henry, Aubrie Harland
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Abstract
Disclosed herein are compounds useful for modulating the mu-opioid receptor (“MOR”) and/or delta-opioid receptor (“DOR”), and methods of using these compounds to treat diseases and conditions, such as pain. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Claims11
A compound of Formula (I):
- wherein:
- A is:
- E is CR1 or N;
- G is S, or SO2;
- n is 0, 1, or 2;
- each R1 independently is H, halo, C1-6alkyl, C1-6haloalkyl, C0-6alkylenearyl, C0-6alkyleneheteroaryl, C0-6alkylenecycloalkyl, C0-6alkyleneheterocycloalkyl, C0-3alkyleneOR4, SR4, SO2R4, C(O)N(R4)2, C(O)OR4, or C(O)SR4;
- and at least one R1 is other than H;
- each R2 independently is H or C1-6alkyl;
- R3 is H, C1-6alkyl, C0-3alkyleneC(O)R4, C0-3alkyleneC(O)OR4 or C0-3alkyleneC(O)NHR4
- R4 is H, C1-6alkyl, C0-3alkylene-C3-6cycloalkyl, C1-3alkylene-OC1-6alkyl, or C0-3alkylenearyl;
- R5 is H, C1-3 alkyl, or C3-6cycloalkyl;
- each R6 independently is H, C1-3alkyl, OH, C1-3alkoxy, halo, or C(O)N(R3)2, and at least one R6 is not H;
- and
- R7 is H, C1-3alkyl, OH, C1-3alkoxy, halo, or C(O)N(R3)2;
- or a pharmaceutically acceptable salt thereof.
12 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.