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US 10,519,108 B2Granted
Inhibitors of retinaldehyde dehydrogenases and methods of use
AssigneesThe Board of Regents of the University of Oklahoma, Oklahoma Medical Research Foundation
InventorsJody A. Summers, Angelica R. Harper, Tim Mather, Anthony Burgett, Anh Thi Quynh Le
Life of this patent
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Abstract
Compounds having inhibitory activity against retinaldehyde dehydrogenases (RALDHs). The compounds can be used, for example, to inhibit synthesis of retinoic acid for the treatment of refractive error disorders such as myopia, and as infertility treatments by inhibiting spermatogenesis.
Claims15
A compound according to formula I:
- wherein
- X is C, O or NH;
- R1 is Cl, F, Br, I, H, NH2, OH, or CH3;
- R2 is Cl, F, Br, I, H, NH2, OH, or CH3, with the proviso that at least one of R1 and R2 is not H;
- R3 is CH3, H, CH2CH3, CH(CH3)2, C6H5, or CH2(C6H5), with either a (R) or (S) configuration;
- R4 is CH3, CH2CH3, CH(CH3)2, C6H5, or CH2(C6H5);
- R5 is CH3, CH2CH3, CH(CH3)2, C6H5, or CH2(C6H5);
- R6 is CH3, CH2CH3, CH(CH3)2, C6H5, or CH2(C6H5);
- and
- R7 is CH3, CH2CH3, CH(CH3)2, C6H5, or CH2(C6H5), with the proviso that at least one of R6 and R7 is CH3.
7 more elements
Dependencies are inferred from the claim text.