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US 10,519,106 B2Granted
Urea derivative and use therefor
AssigneeToray Industries, Inc.
InventorsYukihiro Nishio, Masashi Yamamoto, Yuko Kubota, Hideyuki Tsutsui, Tomohide Masuda, Keiichi Okimura, Syuji Udagawa, Mie Kaino, Hiroyuki Meguro, Yumiko Sekiya
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Abstract
A compound has inhibitory activity on Discoidin Domain Receptor 1. The compound includes a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.
Claims8
A urea derivative represented by Formula (I):
- wherein
- m is 0 or 1;
- R1 is a halogen atom, trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl;
- R2 is a hydrogen atom or methyl in which one hydrogen atom is replaced with hydroxyl, piperazinyl, or 4-methylpiperazinyl;
- R3 is a hydrogen atom or R5O—;
- R4 is phenyl which is optionally substituted;
- R5 is C1-C3 alkyl, 3-oxetanyl, or 4-piperidyl,
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.