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US 10,518,107 B2Granted
Photosensitive cardiac rhythm modulation systems
AssigneePresident and Fellows of Harvard College
InventorKevin Kit Parker
Life of this patent
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Abstract
Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.
Claims23
A photosensitive rhythm modulation tissue structure, comprising
- a flexible polymer layer and
- a genetically engineered anisotropic photosensitive tissue attached to the flexible polymer layer and comprising a population of electrically coupled pacing cells expressing a photosensitive membrane transport mechanism, the photosensitive rhythm modulation tissue structure in contact with a voltage-sensitive or a calcium-sensitive dye enabling optical detection of an electrophysiological change in the electrically coupled pacing cells.
Dependencies are inferred from the claim text.