Delivery system and process
AssigneePolyPharma Pty Ltd
InventorsHarry Unger, Mark Unger, Donald Martin, David John Bull, Craig Andrews
Life of this patent
Estimating the term…
Abstract
A delivery system, including: a material for storing molecules and/or nanoparticles by substantially binding said molecules and/or nanoparticles to said material; a means for applying an electric field to said material to release said molecules and/or nanoparticles; and a means for applying an ultrasonic signal to said material to transport said molecules and/or nanoparticles through said material to a surface for delivery to an entity.
Claims36
A delivery process to non-invasively deliver molecules and/or particles to a choroid and/or retina in a posterior segment of an eye, the delivery process, comprising applying an ultrasonic signal to a polymeric material in contact with an external surface overlying sclera of the eye to:
- release the molecules and/or particles substantially bound within the polymeric material, wherein the molecules and/or particles are substantially bound through:
- i) the polymeric material comprising an electrical charge and the molecules and/or particles comprising an electrical charge opposite to the electrical charge of the polymeric material;
- and/or
- ii) the molecules and/or particles being physically trapped within the polymeric material;
- transport the released molecules and/or particles through the polymeric material to a surface of the polymeric material that is in contact with the external surface overlying sclera of the eye;
- and
- enhance permeability of the sclera of the eye to facilitate delivery of the molecules and/or particles into a uveal tract of the eye and thereby deliver the molecules and/or particles to the choroid and/or retina in the posterior segment of the eye.
A delivery system to non-invasively deliver molecules and/or particles to a choroid and/or retina in a posterior segment of an eye, the delivery system, comprising:
- a polymeric material for storing the molecules and/or particles, wherein the molecules and/or particles are substantially bound within the polymeric material and the molecules and/or particles are substantially bound through:
- i) the polymeric material comprising an electrical charge and the molecules and/or particles comprising an electrical charge opposite to the electrical charge of the polymeric material;
- and/or
- ii) the molecules and/or particles being physically trapped within the polymeric material;
- and
- an ultrasound generator configured to apply an ultrasonic signal to the polymeric material to release the molecules and/or particles and to transport the released molecules and/or particles through the polymeric material to a surface of the polymeric material that is in contact with an external surface overlying sclera of the eye;
- and to enhance permeability of the sclera of the eye to facilitate delivery of the molecules and/or particles into a uveal tract of the eye, and thereby deliver the molecules and/or particles to the choroid and/or retina in the posterior segment of the eye.
Dependencies are inferred from the claim text.