Regional ant-coagulation system for an extracorporeal circulation circuit

An extracorporeal circuit for regional anti-coagulation of blood, comprising:

• a line for taking the blood from a patient, a first filtering unit, and a line for returning the blood to the patient defining a main circuit, the first filtering unit operable to separate plasma water from the blood;
• a secondary circuit for recirculation of the plasma water from the first filtering unit, the secondary circuit comprising:
• a calcium removal assembly configured to receive the plasma water from the first filtering unit and adapted to provide a solution with low calcium content with respect to the plasma water provided from the first filtering unit in the main circuit;
• a first line adapted to infuse the solution with low calcium content into the main circuit upstream of the first filtering unit and of the calcium removal assembly with respect to a blood flow direction in the main circuit;
• and
• a second line for infusion of an electrolytic re-establishment solution located downstream of the first line with respect to the direction of the blood flow in the main circuit.