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US 10,518,002 B2Granted
Intraocular drug delivery and filter device and methods of using same
AssigneeThe Regents of the University of Colorado, a body corporate
InventorJeffrey Olson
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Abstract
The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
Claims20
A method of treating macular degeneration in a subject, the method comprising the steps of:
- implanting into an eye of the subject, and in contact with a fluid of the eye, a device comprising polyacrylonitrile fibers;
- the polyacrylonitrile fibers having a high affinity for and capturing complement factor D from the fluid;
- leaving the device in the eye for a period of time to reduce or alleviate one or more symptoms of macular degeneration;
- and
- regenerating the device in situ by exposing the device to a thermal laser sufficient to denature and release a captured amount of the complement factor D.
2 more elements
A method of treating retinal neovascularization in a subject, the method comprising the steps of:
- implanting into an eye of the subject, and in contact with a fluid of the eye, a device comprising hydroxyapatite;
- the hydroxyapatite having a high affinity for and capturing vascular endothelial growth factor from the fluid;
- leaving the device in the eye for a period of time to reduce or alleviate one or more symptoms of retinal neovascularization;
- and
- regenerating the device in situ by exposing the device to a thermal laser sufficient to denature and release a captured amount of the vascular endothelial growth factor.
2 more elements
Dependencies are inferred from the claim text.