Bioengineered allogeneic blood vessel
AssigneeVeriGraft AB
InventorsSuchitra Sumitran-Holgersson, Michael Olausson
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Abstract
The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
Claims10
A blood vessel produced by a method comprising introducing whole blood comprising endothelial cells, smooth muscle cells, and/or progenitor cells for endothelial and smooth muscle cells from a patient to the lumen of a decellularized blood vessel from a donor, wherein the donor is not the patient, wherein the patient is human, and culturing said cells on the decellularized blood vessel, thereby recellularizing the blood vessel.
Dependencies are inferred from the claim text.