Porous composite, bone regeneration material, and method for producing porous composite
AssigneeToyobo Co., Ltd.
InventorsAtsushi Iwai, Fumihiko Kajii, Hidenori Tanaka
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Abstract
Provided are a porous composite containing OCP and collagen having higher compressive strength than before; a bone regeneration material containing the same; and a method for producing a porous composite. The porous composite contains octacalcium phosphate and collagen, has a pore size of 5 μm to 40 μm as determined by measurement using a mercury porosimeter, and contains pores of 71 μm to 200 μm at a rate of less than or equal to 8% in all pores of less than or equal to 200 μm.
Claims17
A porous composite, comprising:
- octacalcium phosphate and collagen,
- wherein the octacalcium phosphate is present as granules in the porous composite,
- wherein the porous composite comprises pores having a size of 5 μm to 40 μm,
- wherein the pore size is a value of micropore diameter showing a maximum value of a peak having a largest area in a micropore distribution curve obtained by measuring pressure by a mercury intrusion method using a mercury porosimeter,
- wherein a volume of pores having a size of 71 μm to 200 μm divided by a volume of all pores having a size of less than or equal to 200 μm, multiplied by 100, is less than or equal to 8% and more than 0%, and
- wherein said porous composite has a compressive strength of greater than or equal to 0.3 MPa.
A method for producing a porous composite comprising octacalcium phosphate and collagen, comprising the steps of:
- (a) adding particles of octacalcium phosphate to a collagen solution,
- (b) freezing a gel, sol or liquid containing octacalcium phosphate and collagen, and
- (c) lyophilizing the frozen gel, sol or liquid,
- wherein said porous composite has a compressive strength of greater than or equal to 0.3 MPa, and
- wherein the freezing of step (b) is performed by dipping the gel, sol or liquid containing octacalcium phosphate and collagen in a liquid refrigerant.
Dependencies are inferred from the claim text.